Can I take magnesium and melatonin together?
No official source we checked describes an interaction or a spacing rule between magnesium and melatonin. The NIH magnesium fact sheet does not mention melatonin [1], and NCCIH's melatonin page does not mention magnesium [2]. NCCIH says people who take medicine should consult their health care providers before using melatonin [2].
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What the sources say about magnesium and melatonin
No source we checked describes how magnesium and melatonin affect each other. Magnesium is a mineral that acts as a cofactor in more than 300 enzyme systems [1]. Melatonin is a hormone that the brain produces in response to darkness, and in the United States melatonin supplements are regulated as dietary supplements [2]. The NIH magnesium fact sheet does not mention melatonin [1], and NCCIH's melatonin page does not mention magnesium [2].
How to time them
No official source gives a spacing rule for these two. NCCIH describes a trial in people with delayed sleep-wake phase disorder in which melatonin was taken 1 hour before the desired bedtime [2]. The NIH gives no time-of-day rule for magnesium; it notes that forms that dissolve well in liquid are absorbed more completely [1]. The adult upper limit for supplemental magnesium is 350 mg a day [1]. NCCIH advises reading and following label instructions, and notes that some melatonin products do not contain what the label lists [2].
Who should ask a doctor or pharmacist first
NCCIH says people taking medicine should consult their health care providers before using melatonin, and people with epilepsy or taking blood thinners need medical supervision [2]. It notes a lack of research on melatonin in pregnancy and breastfeeding, and that melatonin may stay active longer in older people and cause daytime drowsiness [2]. Magnesium interacts with oral bisphosphonates and tetracycline and quinolone antibiotics, and people with impaired kidney function have a higher risk of magnesium toxicity [1]. Ask your pharmacist.
Supin schedules what you take around each other
Supin puts what you take into a daily routine by time of day, follows each product's label, and reminds you.
Questions people ask next
Sources
- Magnesium: Fact Sheet for Health Professionals — NIH Office of Dietary Supplements
- Melatonin: What You Need To Know — National Center for Complementary and Integrative Health (NCCIH)
Educational information, not medical advice, and not a recommendation for you. Check with your doctor or pharmacist before starting, combining or changing supplements, especially if you take medication, are pregnant or have a health condition. Supin sells a subscription, not supplements. Last reviewed .